a(CHEBI:nicotine) increases act(p(FPLX:CHRN))

PubMed:21482353

Nicotine both activates and desensitizes nAChRs in midbrain dopaminergic neurons (Brodie, 1991; Pidoplichko et al., 1997), and the pleasurable effects associated with nicotine intake occur in large part via the mesolimbic dopaminergic reward system (Corrigall et al., 1992; Koob and Volkow,2010)

MeSH

Dopaminergic Neurons

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