path(MESH:"Parkinson Disease") association p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia"))

PubMed:19126755

In the basal ganglia, including the ventral tegmental area (VTA) and substantia nigra, the alpha6 and possibly the beta3 nAChR subunits are included in alpha4beta2 nAChR complexes to generate highaffinity receptors. At present, this is the only brain area identified where alpha6 and beta3 are coexpressed with alpha4 and beta2 nAChR subunits. This finding is highly relevant for Parkinson’s disease (385, 386).

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• p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease")

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