p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction")

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PubMed:26671985

We performed immunohistochemistry and immunofluorescence on fixed brain sections and biochemical analysis of fresh brain extracts to characterize the presence of PAD-exposed tau (TNT1 antibody), tau oligomers (TOC1 antibody), tau phosphorylated at S422 (pS422 antibody), and tau truncated at D421 (TauC3 antibody) in the brains of 9-11 cases with CTE and cases of nondemented aged controls and AD (Braak VI) (n = 6, each). These 4 markers are particularly useful in understanding potential posttraumatic events in CTE because PAD exposure impairs axonal transport (24), oligomers confer toxicity (28, 38–40), pS422 correlates with cognitive decline (15), and D421 truncated tau may be related to cell toxicity (41, 42). All 3 early tau markers (ie, TNT1, TOC1, and pS422) were present in CTE and displayed extensive colocalization in perivascular tau lesions that are considered diagnostic for CTE.

Related Edges 6

• p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
• p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport")
• p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*"))
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
• p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
• p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity)

MeSH

Chronic Traumatic Encephalopathy

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