act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))

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PubMed:21311567

Furthermore, silencing of both MARK1 and MARK2 blocked DAPK-induced tau S262 phosphorylation (Figure 3e). More importantly, a decrease of pS262 tau, but not total tau, was observed in brain extracts derived from DAPK−/− mice, compared with that from DAPK+/+ mice (Figure 3f). These results strongly suggest a role of endogenous DAPK in stimulating the activity of endogenous MARK, which in turn phosphorylates tau in neurons.

Related Edges 3

• p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1))
• p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2))
• act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))

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