a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

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PubMed:19293145

In addition to nicotine, donepezil and rivastigmine, AChE inhibitors currently used as treatments for mild or moderate AD under the brand names of Aricept and Exelon, also protect cultured neuroblastoma cells from the toxic effects of Abeta. Although there is evidence that, in addition to inhibiting AChE, these ligands are also allosteric modulators of nAChRs (Schrattenholz et al., 1996; Coyle et al., 2007), it has not been established whether these AChE inhibitors protect neurons by their actions on alpha7 nAChRs rather than by simply inhibiting AChE, thereby elevating ACh in the medium.

Related Edges 3

• a(CHEBI:donepezil) decreases path(HBP:neurotoxicity)
• a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity)
• a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

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