complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process")

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PubMed:30444369

In another study, neurons from Tg mAPP/ABAD mice were shown to exhibit decreased activity of cyclooxygenase (COX) enzyme, spontaneous release of ROS, loss of mitochondrial membrane potential, a decrease in ATP production and release of cytochrome c from mitochondria with subsequent induction of caspase-3-like activity followed by apoptotic cell death.

Related Edges 5

• complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species")
• complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX))
• complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential")
• complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP)
• complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3))

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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