act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, loc(MESH:Dendrites)))

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PubMed:30145931

Treatment with rolipram (10 µM) on the neuritic side for 24 h (Fig. 5C) supressed missorting of MAPT down to 4.5±0.4% dendrites, far below the control level (20.5±5.6% dendrites) (Fig. 5D), thereby confirming the role of the proteasome in degrading dendritic MAPT.

Related Edges 2

• a(CHEBI:rolipram) increases act(p(FPLX:Proteasome))
• a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites))

Confidence

Medium

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