a(CHEBI:celastrol) decreases act(p(FPLX:HSP90))

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PubMed:29311797

The Cdc37/Hsp90 inhibitors, Celasterol and Withaferin A (Zhang et al., 2008; Yu et al., 2010), reduce tau levels and a new compound, platycodin D has just been discovered (Li et al., 2017). Platycodin D does not affect the ATPase activity of Hsp90, but instead disrupts the interaction between Hsp90 and Cdc37 leading to client protein degradation without an increase in Hsp70 (Li et al., 2017).

Related Edges 4

• a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90))
• a(CHEBI:"withaferin A") decreases p(HGNC:MAPT)
• a(CHEBI:celastrol) decreases p(HGNC:MAPT)
• a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37))

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