a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid")

PubMed:19126755

In the normal brain, 70% of KYNA formation is catalyzed by KAT II, one of the three cerebral KATs (199, 200). Systemic treatment of rats and mice with kynurenine leads to an elevation of brain levels of several neuroactive intermediates, including KYNA, the free radical generator 3-hydroxykynurenine, and the excitotoxic quinolinic acid (419).

Related Edges 3

• a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine")
• a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid")
• act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid")

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