a(HBP:C646) directlyDecreases act(p(HGNC:EP300))

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PubMed:20869593

Next, we treated primary neurons with C646, a pyrazolone-containing small-molecule inhibitor of p300 with a Ki of 400 nM (Bowers et al., 2010). Under cell-free conditions, C646 at 10 μM inhibits p300 in a highly selective manner (86% inhibition vs. <10% for the six other acetyltransferases) (Bowers et al., 2010). Inhibition of p300 with C646 (20 μM) drastically reduced levels of ac-tau in primary neurons within 8 h.

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• a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac))

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