a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity)

PubMed:19721446

As with nicotine, the weak alpha7 nAChR agonist GTS-21 is neuroprotective, specifically protecting against Abeta1–42-elicited neurotoxicity154. This effect is probably due to small, protracted increases in receptor-mediated Ca2+ influx. importantly, high concentrations of GTS-21 reduced cell survival, underlining the possible risk of over-stimulation152

Related Edges 3

• a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection)
• a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42"))
• a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival")

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