path(MESH:D060825) increases act(p(HGNC:CHAT))

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PubMed:18986241

In MCI, increased hippocampal and frontal cortex ChAT tone may be important for promoting biochemical activity or compensating for neurodegenerative defects, which may delay the transition of these subjects to frank AD. Hippocampal ChAT activity was increased selectively in MCI cases with high Braak scores (Braak III/IV stage) indicative of advanced disease [19], suggesting that a compensatory upregulation of ChAT may be due, at least in part, to the disconnection of glutamatergic entorhinal cortex input to the hippocampus which occurs early in the disease process [21–23]. In this scenario, upregulation of hippocampal ChAT activity may be due to reactive synaptogenesis, the filling in of denervated glutamatergic synapses by cholinergic input arising from the septum [24].

Related Edges 2

• act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration)
• path(MESH:D060825) decreases a(MESH:D013569)

MeSH

Frontal Lobe

MeSH

Hippocampus

MeSH

Cognitive Dysfunction

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