p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration)

PubMed:19126755

The importance of retaining the high-affinity nicotine binding sites to brain integrity has been demonstrated in studies of mice with a null mutation in the gene that encodes the beta2 nAChR subunit, a structural subunit of the high-affinity nicotine binding site (150, 184, 215, 311); these mice experience early onset neurodegeneration (528).

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• path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2)

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