p(GFAM:"Protein phosphatase catalytic subunits") increases p(HGNC:MAPT, pmod(Ph))

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PubMed:18986241

In addition, subunits of protein phosphatase PP1 (Unigene-NCBI annotation PPP1CA and PPP1CC) mRNAs were downregulated in CBF neurons in AD [135]. This observation is interesting in light of the observation that PP1 can phosphorylate tau on several serine/threonine residues and experimental downregulation of PP1 activity leads to increased tau hyperphosphorylation [137,138], which may affect NFT formation in CBF neurons.

Related Edges 5

• bp(HBP:hyperphosphorylation) association path(MESH:D016874)
• act(p(GFAM:"Protein phosphatase catalytic subunits")) decreases bp(HBP:hyperphosphorylation)
• path(MESH:D000544) decreases r(HGNC:PPP1CA)
• path(MESH:D000544) decreases r(HGNC:PPP1CC)
• path(MESH:D016874) association bp(HBP:hyperphosphorylation)

Disease Ontology (DO)

Alzheimer's disease

MeSH

Cholinergic Neurons

MeSH

Cognitive Dysfunction

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