p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates")

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PubMed:27491084

In a yeast model expressing the N-terminal fragment of a polyQ-containing huntingtin protein, overexpression of the yeast HSP70 (SSA1) reduced aggregate formation, whereas the dominant-negative version of the fly homolog to HSPA1L, Hsc4-K71S, enhanced neurodegeneration (Warrick et al., 1999;)

Related Edges 1

• p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration)

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