bp(GO:"inflammatory response") increases p(HGNC:DKK1)

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PubMed:18494933

For example, ongoing inflammation can trigger various cell stress-response pathways, including overexpression of the secreted glycoprotein Dickopff-1 (DKK-1). DKK-1 up-regulates GSK-3β activity, promotes tau hyper-phosphorylation, NFT formation and neuronal degeneration. Thus, DKK-1 inhibits Wnt signalling in a manner similar to Aβ, and thereby fosters a self-sustaining feedback loop resulting in cellular injury

Related Edges 3

• act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
• p(HGNC:DKK1) increases act(p(HGNC:GSK3B))
• p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway")

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