p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))

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PubMed:26631930

Tau protein with mutations in or near the microtubule-binding domain (for instance, G272V, N279K, ΔK280, P301L, V337M or R406W) tend to have a reduced affinity for microtubules and an increased tendency for aggregation

Related Edges 11

• p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
• p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates")

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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