p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration)

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PubMed:26390242

The acetyl-mimicking mutant K174Q slows tau turnover and induces cognitive deficits in vivo. Acetyltransferase p300-induced tau acetylation is inhibited by salsalate and salicylate, which enhance tau turnover and reduce tau levels. In the PS19 transgenic mouse model of FTD, administration of salsalate after disease onset inhibited p300 activity, lowered levels of total tau and tau acetylated at K174, rescued tau-induced memory deficits and prevented hippocampal atrophy.

Related Edges 8

• a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300))
• a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174))
• a(CHEBI:salsalate) decreases p(HGNC:MAPT)
• a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus)
• a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate)
• p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
• p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))

Uberon

hippocampal formation

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