a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))

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PubMed:24183963

Primary hippocampal neuron cells at different concentrations (0, 50, 100, 200 lg/ml) of glucose–BSA were incubated together for 24 h, and then thr205- phosphorylated tau was estimated by the western immunoblotting method. Western blot analysis of each experimental group showed that glucose–BSA promoted tau thr205-phosphorylation in a concentration-dependent manner (Fig. 3(a)). In the present study, it was also shown that 100 nM GLP-1 or Ex-4 treatment reduced tau hyperphosphorylation induced by glucose–BSA (Fig. 3(b, c)).

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• p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))

Uberon

hippocampal formation

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