p(HBP:"Tau C3") increases a(HBP:"Tau aggregates")

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PubMed:24027553

For example, as discussed above, certain modified forms of tau, such as caspase-cleaved tau, have a stronger tendency to aggregate. As tau begins to assemble into oligomers, it may become increasingly undesirable as a proteasomal substrate. These low-order, soluble oligomers may be preferentially degraded by autophagy.

Related Edges 3

• bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates"))
• bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers"))
• act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers"))

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