p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))

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PubMed:29281045

Western blot analyses showed a decrease of methyl-PP2A and an increase of demethyl-PP2A with a concomitant reduction in the methyl/demethyl PP2A ratio in both PSP (74%) and AD (76%) brains, associated with an LCMT-1 decrease and a demethylating enzyme increase, protein phosphatase methylesterase (PME-1), in both diseases.

Related Edges 5

• p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
• path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1)
• path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89")
• path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1)
• path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89")

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