act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph))

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PubMed:24590577

Stimulation of M1 mAChR by two agonists, carbachol and AF102B, time- and dose-dependently decreases tau phosphorylation in PC12 cells[81]. Chronic treatment with AF267B also alleviates tau pathology in 3×Tg AD mice, possibly by activating PKC and inhibiting GSK-3beta

Related Edges 3

• a(CHEBI:carbachol) increases act(p(HGNC:CHRM1))
• a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph))
• a(MESH:cevimeline) increases act(p(HGNC:CHRM1))

Experimental Factor Ontology (EFO)

PC12

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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