act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))

View Subject View Object

PubMed:10998059

Alsterpaullone, the most active paullone, was demonstrated to act by competing with ATP for binding to GSK-3beta. Alsterpaullone inhibits the phosphorylation of tau in vivo at sites which are typically phosphorylated by GSK-3beta in Alzheimer's disease. Alsterpaullone also inhibits the CDK5/p25-dependent phosphorylation of DARPP-32 in mouse striatum slices in vitro.

Related Edges 5

• a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin))
• a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph))
• a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin))
• a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph))
• act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---