p(HGNC:IL18) increases bp(GO:"inflammatory response")

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PubMed:24561250

Interleukins, in particular IL-1β and IL-18, are upregulated in AD brain, and the overexpression of IL-1β or IL-18 is critical for the onset of the inflammatory process (Rubio-Perez and Morillas-Ruiz, 2012), and both mediate the expression of a vast array of inflammatory genes (Weber et al., 2010)

Related Edges 5

• p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:IL1B) increases bp(GO:"inflammatory response")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18)

Confidence

High

NeuroMMSigDB

Inflammatory response subgraph

NeuroMMSigDB

Interleukin signaling subgraph

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