a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases")

PubMed:19126755

Notably, mice with a null mutation in the gene that encodes the alpha5 nAChR subunit exhibit enhanced sensitivity to induction of inflammatory bowel disease relative to controls (353). Despite increased sensitivity to disease initiation, administration of transdermal nicotine remains effective in attenuating the disease process. Therefore, again nicotine appears to impact on inflammatory processes with considerable specificity and tissue dependency.

Related Edges 1

• p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases")

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