a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid")

PubMed:19721446

Amyloid plaques form in the entorhinal cortex of patients with Alzheimer’s disease and this region, which connects the neocortex and the hippocampus, plays a crucial part in memory. it has been suggested that plaques in this region represent the lytic remnants of degenerated, Abeta1–42-burdened pyramidal neurons, and that amyloid internalization depends on alpha7 nAChR mediated Ca2+ entry162. Of interest, chronic nicotine treatment has been shown to reduce the plaque burden in animal models of Alzheimer’s disease123.

Related Edges 3

• a(MESH:"Entorhinal Cortex") association bp(GO:memory)
• bp(GO:memory) association a(MESH:"Entorhinal Cortex")
• path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid")

MeSH

Alzheimer Disease

Text Location

Review

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