p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development")

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PubMed:20133804

Because one role of Tau is to stimulate neurite outgrowth (12), we investigated the consequence of FKBP52 overexpression on neurite length in both PC12 and H7C2 cells. The inhibition of neurite outgrowth resulting from FKBP52 overexpression is in agreement with our previous report showing that the loss of FKBP52 in PC12 cells results in the formation of neurite extensions (9). The FKBP52 effect on neurite length could be explained by the binding of Tau to FKBP52, removing Tau from microtubules.

Related Edges 2

• bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4)
• act(p(RGD:Mapt)) increases bp(GO:"neuron projection development")

Experimental Factor Ontology (EFO)

PC12

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