a(CHEBI:"amyloid-beta") decreases a(GO:synapse)

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PubMed:25514383

The explanation proposed by the authors is that alpha7 nAChR activation through nicotine binding could promote survival pathways and recover the synaptic damage caused by Abeta (Inestrosa et al., 2013)

Related Edges 3

• a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
• act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival")
• act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse)

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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