p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates")

View Subject View Object

PubMed:26631930

Depending on the sites, the acetylation of tau could inhibit its degradation (for example, when at Lys163, Lys280, Lys281 or Lys369) or, by contrast, facilitate its degradation and suppress its phosphorylation and aggregation (for example, when at Lys259, Lys290, Lys321 or Lys353)

Related Edges 15

• p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163)))
• p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259)))
• p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280)))
• p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281)))
• p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290)))
• p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321)))
• p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353)))
• p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369)))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---