path(MESH:D000544) decreases r(GFAM:Synaptotagmins)

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PubMed:18986241

Single cell gene array studies have shown that synaptic transcripts are selectively downregulated in CBF neurons in AD, with significant reductions in synaptophysin and synaptotagmin but not synaptobrevin or SNAP29 mRNA [134,135]. Intriguingly, synaptotagmin function is related to vesicle-presynaptic membrane fusion and neurotransmitter release, suggesting that perturbations in presynaptic vesicle trafficking comprise a common event in vulnerable neuronal populations in AD. In contrast to synaptic transcripts, mRNAs encoding APP and Notch were unchanged between control and AD subjects, whereas acid hydrolase cathepsin D mRNA was upregulated in AD [134–136].

Related Edges 10

• bp(GO:"GO:0007269") association p(GFAM:Synaptotagmins)
• bp(GO:"GO:0031629") association p(GFAM:Synaptotagmins)
• p(GFAM:Synaptotagmins) association bp(GO:"GO:0031629")
• p(GFAM:Synaptotagmins) association bp(GO:"GO:0007269")
• path(MESH:D000544) decreases r(HGNC:SYP)
• path(MESH:D000544) causesNoChange r(HGNC:VAMP1)
• path(MESH:D000544) causesNoChange r(HGNC:SNAP29)
• path(MESH:D000544) causesNoChange r(HGNC:APP)
• path(MESH:D000544) causesNoChange r(HGNC:NOTCH1)
• path(MESH:D000544) increases r(HGNC:CTSD)

MeSH

Cognitive Dysfunction

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