act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))

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PubMed:28877763

Altogether, these data suggest that only certain pathogenic forms of tau (MC1, Y18) promote Syk activation, whereas Syk activation appears to directly in- duce tau phosphorylation at Y18 and to indirectly regulate tau phosphorylation at multiple epitopes (S396/404, S202) as well as tau misfolding (MC1, TOC1).

Related Edges 4

• p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK))
• act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
• act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
• act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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