a(MESHC:"gambogic amide") decreases bp(HBP:Excitotoxicity)

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PubMed:18986241

Gambogic amide binds selectively to TrkA (but not TrkB or TrkC), phosphorylates TrkA tyrosine residues, and activates the Akt and MAPK TrkA-mediated NGF signaling pathways. Gambogic amide has been demonstrated to ameliorate excitotoxic damage and promote neurite outgrowth in PC12 cells [116], making this a potential lead compound for chemical modification and clinical trial assessment.

Related Edges 4

• a(MESHC:"gambogic amide") increases bp(GO:"GO:0031175")
• complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(Ph))
• p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491")
• p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165")

Experimental Factor Ontology (EFO)

PC12

MeSH

Cognitive Dysfunction

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