a(HBP:"sAPP-beta") decreases act(a(CHEBI:"amyloid-beta"))

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PubMed:19293145

Nicotine stimulates the secretion of betaAPP, which is trophic and neuroprotective against Abeta, from PC12 cells through an alpha7 and calcium-dependent pathway (Kim et al., 1997) as well as increasing the secretion of soluble APP and lowering the Abeta-containing sAPP-gamma in rats (Lahiri et al., 2002), again through nAChR-dependent mechanisms. Galantamine, a nAChR potentiator and AChE inhibitor, also increases the secretion of sAPP from human SH-SY5Y neuroblastoma cells (Lenzken et al., 2007) through the activation of nAChRs. It therefore seems that activation of nAChRs shifts the balance of APP processing away from beta-amyloidogenic to soluble APP production.

Related Edges 5

• a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta"))
• a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma")
• p(HGNC:CHRNA7) increases a(CHEBI:nicotine)
• act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta"))

Experimental Factor Ontology (EFO)

PC12

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