act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10))

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PubMed:24590577

Interestingly, stimulation of M1 mAChR by agonists has been found to enhance sAPPalpha generation and reduce Abeta production[61-70]. Protein kinase C (PKC) is well-known to be activated upon stimulation of M1 mAChR. PKC may promote the activity of alpha-secretase[71] and the traffi cking of APP from the Golgi/ trans-Golgi network to the cell surface

Related Edges 4

• act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha")
• act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta")
• act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
• act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface"))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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