a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta")

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PubMed:30116051

The ‘anti-ageing’ agent resveratrol is thought to indi- rectly recruit AMPK via activation of calcium/calmodulin- dependent protein kinase kinase 2 (CAMKK2), which, acting in synergy with Ca 2+ , exerts its effects via Thr172 phosphorylation 113 . This action, among others (below), is involved in its reduction of Aβ levels in N2a cells and neurons 114 and the elimination of Aβ and Htt in animal models of AD and HD 114,115 .

Related Edges 3

• a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2))
• a(CHEBI:resveratrol) decreases p(HGNC:HTT)
• composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172))

MeSH

Dopaminergic Neurons

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