bp(GO:memory) association p(HGNC:CHRM1)

View Subject View Object

PubMed:24590577

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory

Related Edges 19

• a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1)
• a(MESH:"Corpus Striatum") association p(HGNC:CHRM1)
• a(MESH:Hippocampus) association p(HGNC:CHRM1)
• a(MESH:Thalamus) association p(HGNC:CHRM1)
• bp(GO:"neuron differentiation") association p(HGNC:CHRM1)
• bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1)
• bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1)
• bp(GO:learning) association p(HGNC:CHRM1)
• p(HGNC:CHRM1) association a(MESH:Hippocampus)
• p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex")
• p(HGNC:CHRM1) association a(MESH:"Corpus Striatum")
• p(HGNC:CHRM1) association a(MESH:Thalamus)
• p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity")
• p(HGNC:CHRM1) association bp(GO:learning)
• p(HGNC:CHRM1) association bp(GO:memory)
• p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction")
• p(HGNC:CHRM1) association bp(GO:"neuron differentiation")
• p(MGI:Chrm1) increases bp(GO:cognition)
• p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---