act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles")

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PubMed:24027553

Furthermore, active caspase co-localizes to NFTs (58), and caspase-cleaved tau is found in AD-affected brain regions, particularly in neurons displaying tangle pathology (59, 60). This includes tau cleaved by caspase-6 in the C-terminus (58–60) as well as in the N-terminus (24). TauC3 is present in AD brain – in neurons and co-localized with NFTs – and inversely correlates with cognitive function (55, 60, 61).

Related Edges 5

• bp(GO:cognition) negativeCorrelation p(HBP:"Tau C3")
• p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition)
• act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*"))
• act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?"))
• path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases))

MeSH

Alzheimer Disease

Text Location

Review

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