p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 65))

View Subject View Object

PubMed:22926167

Because Pin1 has at least 4 major isovariants in addition to the native polypeptide, this means that Pin1 has 4 (possibly more) posttranslational modifications including phosphorylation at 3 sites (Ser16 and Ser65/Ser71), N-acetylation (amino-terminus and Lys46) and oxidation (Met130 and 146). In all experimental conditions, including tau-overexpressing cells, tau transgenic mice and AD brains, global levels of Pin1 posttranslational modifications were decreased compared with control conditions.

Related Edges 7

• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71))
• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 16))
• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ac, Lys, 46))
• p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---