p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458))

PubMed:19721446

The binding site on alpha7 nAChRs63,64 for the positive allosteric modulators PNu-120596 and lY-2087101, has been tentatively identified within the transmembrane domain. it comprises five amino acids within TM1, TM2 and TM4 which, when mutated, substantially reduce the potentiation of alpah7 nAChRs by allosteric modulators

Related Edges 11

• act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255"))
• act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280"))
• act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490"))
• act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255"))
• act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280"))
• act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490"))
• p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))
• p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458))
• p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))
• p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458))
• p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.