composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies)

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PubMed:29191965

Loss of function in other genes (cat-2, cat-4, tph-1) that also regulate the dopamine or serotonin levels (130–132),did not affect the tau-induced toxicity in TauV337M; however, their activity is essential for bas-1-mediated suppression of tau-induced toxicity in TauV337M (105)

Related Edges 11

• composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies)
• p(HGNC:GCH1) regulates a(CHEBI:dopamine)
• p(HGNC:GCH1) regulates a(CHEBI:serotonin)
• p(HGNC:GCH1) regulates act(p(HGNC:DDC))
• composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies)
• p(HGNC:TH) regulates a(CHEBI:dopamine)
• p(HGNC:TH) regulates a(CHEBI:serotonin)
• p(HGNC:TH) regulates act(p(HGNC:DDC))
• p(HGNC:TPH1) regulates a(CHEBI:dopamine)
• p(HGNC:TPH1) regulates a(CHEBI:serotonin)
• p(HGNC:TPH1) regulates act(p(HGNC:DDC))

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