complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle")

View Subject View Object

PubMed:10391244

This result confirms previous findings that T231 is an important Cdc2 phosphorylation site in tau, and is also consistent with Pin1 binding mitotically pTau (Fig. 1a) and being sequestered on to PHFs in AD brains, where Cdc2 is upregulated (Fig. 3).

Related Edges 4

• complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39")))
• complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1)
• act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
• p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---