a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5))

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PubMed:23737518

Small molecules in the diaminothiazole class are potent Tau kinase inhibitors that target CDK5 and GSK3β. Lead compounds from the series have IC50 values toward CDK5/p25 and GSK3β in the low nanomolar range and no observed toxicity in the therapeutic dose range. Neuronal protective effects and decreased PHF-1 immunoreactivity were observed in two animal models, 3×Tg-AD and CK-p25. Treatment nearly eliminated Sarkosyl-insoluble Tau with the most prominent effect on the phosphorylation at Ser-404. Treatment also induced the recovery of memory in a fear conditioning assay.

Related Edges 7

• a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1")
• a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25"))
• a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b))
• a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5))
• a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b))
• a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5))
• a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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