a(CHEBI:lactacystin) increases p(HGNC:MAPT)

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PubMed:24027553

Additionally, incubation of rat brain extract (containing endogenous tau and proteasomal enzymes) with the proteasome activators Mg2+ and ATP resulted in lower total tau levels with an increase in smaller forms, compared to extract not supplemented with Mg2+ and ATP (73). The loss of tau was blocked by lactacystin giving further evidence that the proteasome was degrading tau (73).

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• a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome))
• act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT))

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