path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process")

View Subject View Object

PubMed:22908190

A continuum of pathological changes of the lysosomal network unfolds in neurons as Alzheimer disease progresses, including dysregulation of endocytosis, increased lysosome biogenesis and, later, progressive failure of lysosomal clearance mechanisms (Fig. 6; Nixon et al. 2006).

Related Edges 5

• a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease")
• bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease")
• bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis)
• path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---