act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region"))

PubMed:19126755

As illustrated in Figure 8, KYNA-induced reduction of extracellular dopamine levels can be explained by the inhibition of tonically active alpha7 nAChRs in the dopaminergic neurons within the VTA and/or in cortical glutamatergic terminals that synapse onto striatal neurons. VTA dopaminergic neurons represent the major dopaminergic input to the nucleus accumbens.

Related Edges 1

• a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7))

MeSH

Dopaminergic Neurons

Text Location

Review

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