a(CHEBI:"amyloid-beta") increases act(p(HGNC:CASP1))

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PubMed:28019679

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14)

Related Edges 4

• a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex"))
• complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis)
• complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027)
• act(p(HGNC:CASP1)) increases bp(GO:pyroptosis)

Confidence

Medium

MeSH

Neurons

NeuroMMSigDB

Apoptosis signaling subgraph

NeuroMMSigDB

Caspase subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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