a(MESH:"Corpus Striatum") association p(HGNC:CHRM4)

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PubMed:24590577

M4 mAChR is mainly expressed in the corpus striatum in the CNS and on various prejunctional nerve terminals in the periphery. M4 mAChR has been suggested to play a role in psychosis and to be a promising target for the treatment of schizophrenia[52]. Indeed, the mixed M1/M4 mAChR agonist xanomeline has antipsychotic effects, and M4 mAChR-knockout mice display increased sensitivity to the disruptive effects of phencyclidine, a drug of abuse

Related Edges 5

• a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders")
• p(HGNC:CHRM4) association a(MESH:"Corpus Striatum")
• p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders")
• p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine))
• path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4)

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