p(FPLX:HSP90) regulates deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))

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PubMed:25374103

Recent data suggest that a critical mediator of refolding or clearance of hyperphosphorylated tau is via the HSP70/HSP90 heat shock pathways in which a specific E3 ubiquitin ligase, CHIP (carboxy terminus Hsp70 interacting protein), can recognize and target for degradation abnormal but not normal tau molecules [14–16].

Related Edges 1

• p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))

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