a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)")

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PubMed:19293145

Application of nicotine to rat microglia results in the up-regulated expression of cyclooxygenase-2 and prostaglandin E2 (De Simone et al., 2005). Signaling pathways downstream to the MAPK pathway are similarly well placed to effect changes in gene expression. For example, alpha7-dependent activation of the MAPK pathway is known to activate c-Myc (Liu et al., 2007), a protooncogene whose transcription product sensitizes cells to pro-apoptotic stimuli.

Related Edges 4

• a(CHEBI:nicotine) increases act(g(HGNC:PTGS2))
• bp(GO:"MAPK cascade") increases act(p(HGNC:MYC))
• p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade")
• act(p(HGNC:MYC)) increases bp(GO:"apoptotic process")

Cell Ontology (CL)

microglial cell

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