p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))

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PubMed:29191965

The responsible kinases include 1) proline-directed protein kinases (PDPKs) targeting SP or TP motifs [e.g., GSK3b, cyclindependent kinase (CDK)-5, and MAPKs]; 2) non–proline directed protein kinases targeting KXGS-motifs [e.g., PKA, microtubule affinity-regulating kinase and synapses of the amphid defective (SADK)]; 3) protein kinases specific for tyrosines (e.g., Src, Lck, Syk, Fyn, and c-Abl kinase) (91).

Related Edges 8

• p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph))
• p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph))
• p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
• p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
• p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
• p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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